【作者】 閆梅霞； 關一鳴； 胡清秀； 張瑞； 王英平； 楊元超；

【Author】 YAN Meixia1,2,GUAN Yiming2,HU Qingxiu1 ,ZHANG Rui2,WANG Yingping2,YANG Yuanchao21Institute of Agricultural Resources and Regional Planning,Chinese Academy of Agricultural Sciences,Beijing 100081,China;2Institute of Special Wild Economic Animal and Plant Science,Chinese Academy of Agricultural Sciences,Jilin,Jilin 132109,China

【機構】 中國農業(yè)科學院農業(yè)資源與農業(yè)區(qū)劃研究所； 中國農業(yè)科學院特產研究所；

【摘要】 對硫磺菌(Laetiporus sulphureus)液體發(fā)酵菌絲粗多糖進行體內抗腫瘤研究,結果表明:硫磺菌粗多糖對Lewis肺癌的體內最大抑制作用為35.7%,粗多糖組對胸腺和脾臟的影響顯著小于環(huán)磷酰胺。

【Abstract】 The antitumor activity of crude polysaccharide from Laetiporus sulphureus mycelium grown in submerged cultured was determined using Lewis lung cancer-bearing mice as the test model.Inhibitory effects on tumor growth were highest(35.7%) in mice administered 100 mg/mL of crude polysaccharide.However,spleen and thymus indices and animal weights were significant higher in polysaccharide-treated mice compared to positive control mice administered cyclophosphamide.

【關鍵詞】 液體發(fā)酵； 粗多糖； 抗腫瘤；

【Key words】 Submerged culture； crude polysaccharide； antitumor activity；

【基金】 國家現(xiàn)代食用菌產業(yè)技術體系的崗位專家專項經(jīng)費資助

【分類號】R734.2