尚德靜; 崔喬; 高林
遼寧師范大學(xué)生命科學(xué)學(xué)院; 遼寧師范大學(xué)生命科學(xué)學(xué)院; 大連醫(yī)科大學(xué)附屬二院 大連116029 ; 大連116029 ; 大連116027

【中文摘要】 靈芝硒多糖SeGLP - 1由葡萄糖、甘露糖、木糖、半乳糖和鼠李糖組成 ,與靈芝多糖一樣是由α -糖苷鍵連接的吡喃多糖 ,硒在多糖內(nèi)極可能是以O(shè) =Se =O的形式結(jié)合。給移植肝腹水癌HCa -f的小鼠每日注射 5 0mg/kg的SeGLP - 1,15d后抑癌率可達(dá) 80 % ,說明SeGLP - 1的抑癌作用與其分子組成和分子結(jié)構(gòu)的變化有關(guān)

【英文摘要】 The polysaccharide containing selenium in Ganoderma lucidum (SeGLP-1), a kind of pyranose linked by α-glucoside bond as GLP-1, was isolated and purified from fermented mycelia of Ganoderma lucidum rich in selenium. Glu,Man,Xyl,Gal and Rha were identified as the components of SeGLP 1 by GC and TLC. The results from IR, 77 Se NMR, 13 C NMR and Laser Raman spectra showed that the selenium structure of SeGLP 1 activity center was O=Se=O,and CH 3 in OCH 3 group was substituted by selenium. SeGLP-1 could distinctly suppress the growth of tumor cell at a daily dosage of 50mg/kg supplied continuously for 15d with an anti HCa-f tumor rate of 80%. And it was confirmed in our experiment that the anti-tumor effect of SeGLP 1 was related to the changes of its molecular components and structure.

【中文關(guān)鍵詞】 靈芝硒多糖; 抑癌作用; 分子結(jié)構(gòu)
【英文關(guān)鍵詞】 Polysaccharide containing selenium in Ganoderma lucidum (SeGLP-1); Anti-tumor activity; Molecular structure
【基金】遼寧省教委重點(diǎn)科研項(xiàng)目 (95 12 10 0 3)

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2001年03期 【DOI】CNKI:SUN:SYJB.0.2001-03-006