閔三弟; 臧珍娣; 宋士良; 勞華均; 嚴(yán)惠芳; 陸宏祺
上海市農(nóng)業(yè)科學(xué)院食用菌研究所!上海201106; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所!上海201106; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所!上海201106; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所!上海201106; 上海醫(yī)藥工業(yè)研究院藥理室!上海200437; 上海醫(yī)藥工業(yè)研究院藥理室!上海200437

【中文摘要】 從靈芝子實(shí)體用熱水提取分離的靈芝多糖（GLP）對(duì)Lewis肺癌和結(jié)腸癌具有相當(dāng)高的抑制生長(zhǎng)活性,并能增強(qiáng)正常小鼠腹腔巨噬細(xì)胞吞噬作用和荷瘤小鼠NK細(xì)胞活性,從而提高機(jī)體免疫功能.靈芝多糖口服給藥劑量每天每公斤C57BL/6小鼠2000mg.足趾接種和腑皮下接種對(duì)Lewis肺癌的抑制率分別為53.54％～59.13 ％和36.43％～42.76％;對(duì)結(jié)腸癌的抑制率分別為42.47％～49.14％和29.43％～32.09％.

【英文摘要】 The polysaccharide of Ganoderma lucidum (GLP), isolated from hot-water extracts of Ganoderma lucidum fruitbody has relatively high growth-inhibition activities against Lewis lung carcinoma and colon cancer and enhances immune function of the mice which took it. GLP is taken orally by C57BL/6 mice at a dosage of 2000mg per day and the inhibition rate of Lewis lung carcinoma by subcutaneous inoculation to mice at toe and axillary is about 53.54 %-59.13 % and 36.43 %-42.76 % respectively. The inhibition rate of colon cancer by inoculation to mice at toe and axillary is about 42.47% -49.13% and 29.43-32.09% respectively. Meanwhile, GLP enhances the phagocytosis of macrophage in abdominal cavity of normal mice and activities of NK cells of tumor-bearing mice.

【中文關(guān)鍵詞】 靈芝; 子實(shí)體; 多糖; 抗腫瘤活性
【英文關(guān)鍵詞】 Ganoderma lucidum; Fruitbody; Polysaccharide; Antitumor activity

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,1996年01期 【DOI】CNKI:SUN:SYJB.0.1996-01-003