張香花; 孫東植; 陳海月; 崔基成; 劉樹森
延邊大學(xué)基礎(chǔ)醫(yī)學(xué)院病理學(xué)與法醫(yī)學(xué)教研部; 延邊大學(xué)基礎(chǔ)醫(yī)學(xué)院病理學(xué)與法醫(yī)學(xué)教研部; 延邊大學(xué)基礎(chǔ)醫(yī)學(xué)院病理學(xué)與法醫(yī)學(xué)教研部; 延邊真菌研究所; 延邊大學(xué)基礎(chǔ)醫(yī)學(xué)院病理學(xué)與法醫(yī)學(xué)教研部 吉林延邊133002; 吉林延邊133002; 吉林延邊133002; 吉林延吉133000; 吉林延邊133002
【中文摘要】 大鼠實(shí)驗(yàn)40d后,脫頸處死,迅速剖腹取胰腺、肝和腎組織,分別進(jìn)行HE染色和免疫組化SABC染色、PAS染色觀察病變。進(jìn)行胰島組織觀察、肝組織觀察、腎組織觀察,結(jié)果表明樺褐孔菌提取物對(duì)STZ誘導(dǎo)的糖尿病大鼠的胰島、肝和腎組織損傷病變有一定的保護(hù)和修復(fù)作用。
【英文摘要】 To observe the protective and prothetic effects of extracts from Inonotus obliquus on pancreatic island,hepatic and kidney injury in streptozocin(STZ)-induced diabetic rats,all rats had been tested for 40 days.We executed them by the method of neck mutilation and took the pancreatic island,hepatic and nephridial tissue from their abdominal cavities.Then we made use of HE staining method,PAS staining method and immunohistochemistry staining method and observed pathological change.To compare high density extracts from Inonotus obliquus group and diabetic model group,the former made the number and bulk of pancreatic island increase.The number of B cell in pancreatic island and insulin-secreting granule in B cell increased.To compare high middle density extracts from Inonotus obliquus group and diabetic model group.The former made the content of glycogen particle in hepatic cell increase remarkably.To compare high middle density extracts from Inonotus obliquus group and diabetic model grou...更多p,the thickening of glomerular basement membrane(GBM)and the hyperplasy of intercapillary cells were not remarkable.The vacuolar degeneration in nephric tubule was lessened remarkably.Extracts from Inonotus obliquus had the protective and prothetic effects on pancreatic island,hepatic and kidney injury in STZ-induced diabetic rats. 還原
【中文關(guān)鍵詞】 樺褐孔菌; 糖尿病大鼠; 胰島; 肝; 腎
【英文關(guān)鍵詞】 Inonotus obliquus; Diabetic rats; Pancreatic island; Hepar; Kidney
【文獻(xiàn)出處】 中國(guó)食用菌,Edible Fungi of China,編輯部郵箱,2008年02期 【DOI】CNKI:SUN:ZSYJ.0.2008-02-013