孫玉軍; 陳彥; 周正義; 周麗偉
安徽科技學(xué)院生命科學(xué)學(xué)院; 安徽大學(xué)生命科學(xué)學(xué)院; 安徽科技學(xué)院生命科學(xué)學(xué)院; 安徽大學(xué)生命科學(xué)學(xué)院 安徽鳳陽233100; 安徽合肥230039; 安徽鳳陽233100; 安徽合肥230039

【中文摘要】 采用CCl4法進行肝損傷造模,測定小鼠血清谷丙轉(zhuǎn)氨酶、谷草轉(zhuǎn)氨酶和肝臟指數(shù)的變化,同時檢測肝勻漿中超氧化物岐化酶(SOD)和丙二醛(MDA)含量。羊肚菌胞內(nèi)多糖能明顯降低血清中的谷丙轉(zhuǎn)氨酶、谷草轉(zhuǎn)氨酶活性,降低肝臟中MDA的含量和肝臟指數(shù),提高SOD活性,并能顯著地減輕CC14引起的肝小葉內(nèi)的灶性壞死。結(jié)果表明羊肚菌胞內(nèi)多糖對小鼠肝臟的損傷有保護作用。

【英文摘要】 To study the protective effects of intracellular polysaccharide from Morchella esculenta(MEP)on acute liver injury caused by CCl4 in mice,the mice were given i.g.MEP daily for 18 days before the models were made by i.p.injection of CCl4.The content of ALT,AST activity were measured in the serum,SOD,MDA were measured in the liver and 1iver index were also detected.MEP could significantly decrease the content of ALT,AST,MDA and liver index,and also improve SOD activity in liver.The lesions in liver lobule were ameliorated obviously.The results showed that MEP had protective effects on mice acute hepatic injury.

【中文關(guān)鍵詞】 羊肚菌; 胞內(nèi)多糖; 四氯化碳; 肝損傷
【英文關(guān)鍵詞】 Acute liver injury; Morchella esculenta; Polysaccharide; Carbon tetrachloride
【基金】安徽省教育廳自然科學(xué)研究項目資助(No.2006KJ203B)

【文獻出處】 中國食用菌,Edible Fungi of China,編輯部郵箱,2008年02期 【DOI】CNKI:SUN:ZSYJ.0.2008-02-017