李常春; 林其祥; 邱淑玉; 劉必雄; 林菁; 林建忠
福建醫(yī)學(xué)院藥理教研室; 福建醫(yī)學(xué)院藥理教研室; 福建醫(yī)學(xué)院藥理教研室; 福建醫(yī)學(xué)院藥理教研室; 福建醫(yī)學(xué)院藥理教研室; 福建醫(yī)學(xué)院藥理教研室 福州; 福州; 福州; 福州; 福州; 福州

【中文摘要】 曾報(bào)告過(guò)中國(guó)擬青霉(CN80—2)的藥理作用,本文僅報(bào)告它與生育調(diào)節(jié)有關(guān)的實(shí)驗(yàn)結(jié)果:1.雄性小鼠以CN80—21.08g/kg×14d灌胃(PO)后,再與雌性小鼠合籠交配,結(jié)果懷孕率與胎仔數(shù)均低于對(duì)照組;2.小鼠妊娠第1天起給藥(PO)CN80—2 20/kg×7d,有顯著的抗著床作用(P<0.01);3.實(shí)驗(yàn)證明CN80—2有極顯著的抗雌激素活性(P<0.001);4.大鼠給予CN80—2(劑量方法同小鼠)后,其血將雌二醇濃度明顯降低而血漿孕酮濃度僅輕度下降;5.小鼠給予CN80—2 80g/kg一次灌胃,無(wú)明顯毒牲。

【英文摘要】 The experiment explores the effect of Cn80—2 on fertility regulation. The experimental results are: 1) Cn80—2 caused an obvious reduction of pregnancy rate and there was a lessening in the number of fetuses in female mice when the male were fed with Cn80—2 orally at the dose of 1.0 g/kg daily for 14 days before their copulation. 2) Cn 80—2 had a remarkble antiimplantation effect in mice at the dose of 20 g/kg p. o. daily for 7 days from the 1st day of pregnancy on. The tests of estrogenic and antiestrogenic activity indicated that tie Cn 80—2 had a remarkable antiestrogenic activity, but no estrogenic activity. 3) After the drug was given p. o. to rats at the dose of 20 g/kg daily for 7 days the plasma concentration of estradial was significantly reduced while that of the progesterone declined only slightly. 4) No apparent toxicity was found in mice with a single dose of 80 g/kg per os.

【中文關(guān)鍵詞】 中國(guó)擬青霉; 妊娠率; 抗著床作用; 雌二醇
【英文關(guān)鍵詞】 Paecilomyces sinensis-sp. nov. antiimplantation effect; fertility regulation; pregnancy rate

【文獻(xiàn)出處】 中國(guó)食用菌,Edible Fungi of China,編輯部郵箱,1991年02期 【DOI】CNKI:SUN:ZSYJ.0.1991-02-007