樟芝菌絲體發(fā)酵全液凍干粉長期食用安全性評估
Safety Assessment of Antrodia cinnamomea Mycelium Grown in Submerged Culture

【作者】 陳泰伊； 仲偉鑒； 肖萍； 洪新宇； 林定威； 許勝杰； 陳勁初；

【Author】 CHEN Taii1,CHONG Weichian2,SHIAO Ping2,HONG Shinyu2,LIN Tingwei1, SHEU Senje1,CHEN Chinchu1 1Grape King Incorporated,Shanghai 201611,China;2Shanghai Institute of Preventive Medicine, Shanghai 200336,China

【機(jī)構(gòu)】 上海葡萄王企業(yè)有限公司； 上海市預(yù)防醫(yī)學(xué)研究院；

【摘要】 對樟芝菌絲體發(fā)酵全液凍干粉進(jìn)行大鼠90d安全性評估試驗(yàn),按樟芝菌絲體發(fā)酵液凍干粉量與大鼠體重比,設(shè)計(jì)低、中、高3個(gè)劑量(0.5、1.5、4.5g/kg)。結(jié)果表明:試驗(yàn)期間所有動(dòng)物生長良好,無明顯掉毛、行動(dòng)遲緩、不吃不喝等臨床癥狀,血液學(xué)、生物化學(xué)、尿常規(guī)、主要臟體比及組織學(xué)檢查結(jié)果與對照組相比,均無明顯差異。樟芝菌絲體發(fā)酵全液凍干粉的無觀察危害反應(yīng)劑量為每天4.5g/kg。

【Abstract】 A 90-day subchronic toxicity test was undertaken to assess the safety of Antrodia cinnamomea(Ac) mycelium grown in submerged culture.Male and female Sprague Dawley rats were administered Ac at doses of 0.0,0.5,1.5 and 4.5 g/kg per day in the normal feed for 90 consecutive days and were observed daily for clinical abnormalities.Body weights and feed intake levels were measured and recorded weekly.All the animals survived until the termination of the study(91 days),at which point they were sacrifi...

【關(guān)鍵詞】 樟芝； 安全性； 長期食用；
【Key words】 Antrodia cinnamomea； safety assessment,subchronic toxicity；

【分類號】TS219