洛巴口蘑濾液中多糖蛋白復(fù)合物的抗腫瘤機(jī)制
ANTITUMOR MECHANISM OF POLYSACCHARIDE-PROTEIN COMPLEX FROM THE CULTURE FILTRATE OF TRICHOLOMA LOBAYENSE
劉方 黃容春 邢來君 趙力 張樹庭
摘 要：從洛巴口蘑培養(yǎng)濾液中分離出一種具有抗腫瘤性的多糖蛋白復(fù)合物(PSPC).PSPC在細(xì)胞水平有能力恢復(fù)和增強(qiáng)帶瘤鼠腹腔浸出細(xì)胞的吞噬功能和T細(xì)胞的促分裂活性.在分子水平,PSPC能恢復(fù)帶瘤鼠脾細(xì)胞和腹腔浸出細(xì)胞內(nèi)IFN-γ基因的表達(dá)水平.另外,PSPC能夠下調(diào)帶瘤鼠脾細(xì)胞內(nèi)"抗細(xì)胞因子”TGF-β的表達(dá)水平.因此,PSPC的抗腫瘤機(jī)制可歸咎于寄主介導(dǎo)的免疫調(diào)節(jié)作用.
關(guān)鍵詞：多糖,蘑菇,細(xì)胞因子,免疫調(diào)節(jié)
分類號(hào)：Q939.93 文獻(xiàn)標(biāo)識(shí)碼：A
文章編號(hào)：1007-3515-62000)03-0396-0400
作者單位：劉方（天津南開大學(xué)微生物系 天津 300071）
黃容春（香港中文大學(xué)生物系 香港）
邢來君（天津南開大學(xué)微生物系 天津 300071）
趙力（天津醫(yī)院 天津 300211）
張樹庭（香港中文大學(xué)生物系 香港）
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